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overview The Novembre research group uses computational tools to study genetic diversity in natural populations. Our goal is to develop widely used statistical methods for intelligently extracting information from large-scale genomic data with the aim to improve understanding of: (1) basic genomic biology, (2) the biology of heritable disease traits, (3) the genetic basis of evolutionary processes, and (4) the history and evolution of various species, especially humans. From a disciplinary perspective, most of the ideas we use are from theoretical population genetics, statistical genetics, and computational statistics. Much of our work is invigorated by addressing data from emerging genotyping and sequencing technologies applied to large or particularly interesting population samples.
One or more keywords matched the following items that are connected to Novembre, John
Item TypeName
Concept Genetic Variation
Academic Article Spatial patterns of variation due to natural selection in humans.
Academic Article Interpreting principal component analyses of spatial population genetic variation.
Academic Article Genes mirror geography within Europe.
Academic Article An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people.
Academic Article Power analysis of artificial selection experiments using efficient whole genome simulation of quantitative traits.
Academic Article Genome sequencing highlights the dynamic early history of dogs.
Academic Article Height-reducing variants and selection for short stature in Sardinia.
Academic Article Visualizing the geography of genetic variants.
Academic Article Recent advances in the study of fine-scale population structure in humans.
Academic Article A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.
Academic Article Population- and individual-specific regulatory variation in Sardinia.
Academic Article Genomic history of the Sardinian population.
Academic Article Natural Selection and Origin of a Melanistic Allele in North American Gray Wolves.
Academic Article Estimating recent migration and population-size surfaces.
Academic Article Genetic Landscapes Reveal How Human Genetic Diversity Aligns with Geography.
Academic Article A variant-centric perspective on geographic patterns of human allele frequency variation.
Academic Article Fast and flexible estimation of effective migration surfaces.
Academic Article The background and legacy of Lewontin's apportionment of human genetic diversity.
Grant Extending Tools for Visualization of Geographic Structure in Population Genomic Data
Grant Population Genetic Consequences of Recent Explosive Population Growth in Humans
Grant Haplotype-based analysis methods for population genomics
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  • Genetic Variation